Publication: Preoperative assessment of CD44-mediated depth of invasion as predictor of occult metastases in early oral squamous cell carcinoma
Preoperative assessment of CD44-mediated depth of invasion as predictor of occult metastases in early oral squamous cell carcinoma
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Morand, G. B., Ikenberg, K., Vital, D. G., Cardona, I., Moch, H., Stoeckli, S. J., & Huber, G. F. (2019). Preoperative assessment of CD44-mediated depth of invasion as predictor of occult metastases in early oral squamous cell carcinoma. Head and Neck, 41(4), 950–958. https://doi.org/10.1002/hed.25532
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BACKGROUND Epithelial-mesenchymal transition and cancer stem-like cells (CSC) have been linked to increased metastatic potential. We evaluated the prognostic impact of CD44, a CSC biomarker, on depth of invasion (DOI) and outcome in oral squamous cell carcinoma (OSCC). METHODS Using a multivariable logistic regression model, we evaluated in early OSCCs the relationship between CD44 expression at the invasive tumor front, DOI, sentinel lymph node biopsy, extension of nodal involvement, and survival. We also assessed whether CT and/o
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- Morand, Grégoire B
- Ikenberg, Kristian
- Vital, Domenic G
- Cardona, Isabel
- Moch, Holger
- Stoeckli, Sandro J
- Huber, Gerhard F
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Morand, G. B., Ikenberg, K., Vital, D. G., Cardona, I., Moch, H., Stoeckli, S. J., & Huber, G. F. (2019). Preoperative assessment of CD44-mediated depth of invasion as predictor of occult metastases in early oral squamous cell carcinoma. Head and Neck, 41(4), 950–958. https://doi.org/10.1002/hed.25532
