Time course of cellular and molecular regulation in the immune system in altered gravity: progressive damage or adaptation?

Thiel, Cora S; Lauber, Beatrice A; Polzer, Jennifer; Ullrich, Oliver

doi:10.1016/j.reach.2017.03.003

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Thiel, C. S., Lauber, B. A., Polzer, J., & Ullrich, O. (2017). Time course of cellular and molecular regulation in the immune system in altered gravity: progressive damage or adaptation? Reach: Reviews in Human Space Exploration, 5, 22–32. https://doi.org/10.1016/j.reach.2017.03.003

Abstract

We summarized the current knowledge about adaptation processes of isolated immune cells, animal models and the human body to altered gravity conditions. Many studies indicate an adaptation reaction of the immune system to the new microgravity environment, at least for the T cell system. Animal and human studies indicated adaptation processes starting after two weeks and continuing until 6 month or longer, which was reflected by cytokine concentrations in blood plasma or in stimulation assays. Adaptive reactions regarding IFN-c, TNF-a