IFN-γ primes keratinocytes for HSV-1-induced inflammasome activation

Strittmatter, Gerhard E; Sand, Jennifer; Sauter, Marlies; Seyffert, Michael; Steigerwald, Robin; Fraefel, Cornel; Smola, Sigrun; French, Lars E; Beer, Hans-Dietmar

doi:10.1016/j.jid.2015.12.022

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Strittmatter, G. E., Sand, J., Sauter, M., Seyffert, M., Steigerwald, R., Fraefel, C., Smola, S., French, L. E., & Beer, H.-D. (2016). IFN-γ primes keratinocytes for HSV-1-induced inflammasome activation. Journal of Investigative Dermatology, 136(3), 610–620. https://doi.org/10.1016/j.jid.2015.12.022

Abstract

Inflammasomes are immune complexes, which induce an inflammatory response upon sensing of different stress signals. This effect is mainly mediated by activation and secretion of the proinflammatory cytokines prointerleukin(IL)-1β and -18. Here we report that infection of human primary keratinocytes with the double-stranded (ds) DNA viruses Modified Vaccinia Virus Ankara (MVA) or Herpes Simplex Virus Type 1 (HSV-1) induced secretion of mature IL-1β and -18. This secretion was dependent on several inflammasome complexes, however, the AI