High hepatic and extrahepatic mortality and low treatment uptake in HCV-coinfected persons in the Swiss HIV cohort study between 2001 and 2013

Swiss HIV Cohort Study; Kovari, Helen; Ledergerber, Bruno; et al

doi:10.1016/j.jhep.2015.04.019

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Swiss HIV Cohort Study, Kovari, H., Ledergerber, B., & et al. (2015). High hepatic and extrahepatic mortality and low treatment uptake in HCV-coinfected persons in the Swiss HIV cohort study between 2001 and 2013. Journal of Hepatology, 63(3), 573–580. https://doi.org/10.1016/j.jhep.2015.04.019

Abstract

BACKGROUND & AIMS The landscape of HCV treatments is changing dramatically. At the beginning of this new era, we highlight the challenges for HCV therapy by assessing the long-term epidemiological trends in treatment uptake, efficacy and mortality among HIV/HCV-coinfected people since the availability of HCV therapy. METHODS We included all SHCS participants with detectable HCV RNA between 2001 and 2013. To identify predictors for treatment uptake uni- and multivariable Poisson regression models were applied. We further used surviv