Publication: Emergent stem cell homeostasis in the C. elegans germline is revealed by hybrid modeling
Emergent stem cell homeostasis in the C. elegans germline is revealed by hybrid modeling
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Hall, B. A., Piterman, N., Hajnal, A., & Fisher, J. (2015). Emergent stem cell homeostasis in the C. elegans germline is revealed by hybrid modeling. Biophysical Journal, 109(2), 428–438. https://doi.org/10.1016/j.bpj.2015.06.007
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Abstract
The establishment of homeostasis among cell growth, differentiation, and apoptosis is of key importance for organogenesis. Stem cells respond to temporally and spatially regulated signals by switching from mitotic proliferation to asymmetric cell division and differentiation. Executable computer models of signaling pathways can accurately reproduce a wide range of biological phenomena by reducing detailed chemical kinetics to a discrete, finite form. Moreover, coordinated cell movements and physical cell-cell interactions are required
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- Hall, Benjamin A
- Piterman, Nir
- Fisher, Jasmin
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Hall, B. A., Piterman, N., Hajnal, A., & Fisher, J. (2015). Emergent stem cell homeostasis in the C. elegans germline is revealed by hybrid modeling. Biophysical Journal, 109(2), 428–438. https://doi.org/10.1016/j.bpj.2015.06.007