Publication: Ovarian cancer G protein-coupled receptor 1 deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice
Ovarian cancer G protein-coupled receptor 1 deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice
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Yassini, N., Sprenger, J., Pastor Arroyo, E. M., Krudewig, C., Pellegrini, G., Joller, N., Wagner, C. A., & Imenez Silva, P. H. (2023). Ovarian cancer G protein-coupled receptor 1 deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice. Clinical Science, 137, 1013–1025. https://doi.org/10.1042/cs20230421
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Ovarian cancer G protein-coupled receptor 1 (OGR1) (Gpr68) and G protein-coupled receptor 4 (GPR4) (Gpr4) are proton-activated G protein-coupled receptors that are stimulated upon increased extracellular acidity. These receptors have various physiological and pathophysiological roles in renal acid–base physiology, tissue inflammation, and fibrosis among others. Their function in injured renal tissue, however, remains mostly unclear. To address this, we investigated their role in crystalline nephropathy by increasing the oxalate intake
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- Yassini, Nima
- Sprenger, Janine
- Pastor Arroyo, Eva Maria
- Krudewig, Christiane
- Pellegrini, Giovanni
- Wagner, Carsten A
- Imenez Silva, Pedro Henrique
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Yassini, N., Sprenger, J., Pastor Arroyo, E. M., Krudewig, C., Pellegrini, G., Joller, N., Wagner, C. A., & Imenez Silva, P. H. (2023). Ovarian cancer G protein-coupled receptor 1 deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice. Clinical Science, 137, 1013–1025. https://doi.org/10.1042/cs20230421
