Publication: Activin tunes GABAergic neurotransmission and modulates anxiety-like behavior
Activin tunes GABAergic neurotransmission and modulates anxiety-like behavior
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Zheng, F., Adelsberger, H., Müller, M. R., Fritschy, J. M., Werner, S., & Alzheimer, C. (2009). Activin tunes GABAergic neurotransmission and modulates anxiety-like behavior. Molecular Psychiatry, 14, 332–346. https://doi.org/10.1038/sj.mp.4002131
Abstract
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Abstract
Activin, a member of the transforming growth factor-beta superfamily, affords neuroprotection in acute brain injury, but its physiological functions in normal adult brain are largely unknown. Using transgenic (tg) mice expressing a dominant-negative activin receptor mutant under the control of the CaMKIIalpha promoter in forebrain neurons, we identified activin as a key regulator of gamma-aminobutyric acid (GABA)ergic synapses and anxiety-like behavior. In the open field, wild-type (wt) and tg mice did not differ in spontaneous locomo
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- Zheng, F
- Adelsberger, H
- Müller, M R
- Fritschy, J M
- Werner, S
- Alzheimer, C
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Zheng, F., Adelsberger, H., Müller, M. R., Fritschy, J. M., Werner, S., & Alzheimer, C. (2009). Activin tunes GABAergic neurotransmission and modulates anxiety-like behavior. Molecular Psychiatry, 14, 332–346. https://doi.org/10.1038/sj.mp.4002131
