Distinct Cerebrovascular Reactivity Patterns for Brain Radiation Necrosis

Muscas, Giovanni; van Niftrik, Christiaan Hendrik Bas; Sebök, Martina; Della Puppa, Alessandro; Seystahl, Katharina; Andratschke, Nicolaus; Brown, Michelle; Weller, Michael; Regli, Luca; Piccirelli, Marco; Fierstra, Jorn

doi:10.3390/cancers13081840

Citations

Citation copied

Muscas, G., van Niftrik, C. H. B., Sebök, M., Della Puppa, A., Seystahl, K., Andratschke, N., Brown, M., Weller, M., Regli, L., Piccirelli, M., & Fierstra, J. (2021). Distinct Cerebrovascular Reactivity Patterns for Brain Radiation Necrosis. Cancers, 13(8), 1840. https://doi.org/10.3390/cancers13081840

Abstract

Background: Current imaging-based discrimination between radiation necrosis versus recurrent glioblastoma contrast-enhancing lesions remains imprecise but is paramount for prognostic and therapeutic evaluation. We examined whether patients with radiation necrosis exhibit distinct patterns of blood oxygenation-level dependent fMRI cerebrovascular reactivity (BOLD-CVR) as the first step to better distinguishing patients with radiation necrosis from recurrent glioblastoma compared with patients with newly diagnosed glioblastoma before su