Publication: Bone marrow transplantation improves proximal tubule dysfunction in a mouse model of Dent disease
Date
Date
Date
2017
Journal Article
Published version
Abstract
Abstract
Abstract
Dent disease is a rare X-linked tubulopathy caused by mutations in the endosomal chloride-proton exchanger (ClC-5) resulting in defective receptor-mediated endocytosis and severe proximal tubule dysfunction. Bone marrow transplantation has recently been shown to preserve kidney function in cystinosis, a lysosomal storage disease causing proximal tubule dysfunction. Here we test the effects of bone marrow transplantation in Clcn5(Y/-) mice, a faithful model for Dent disease. Transplantation of wild-type bone marrow in Clcn5(Y/-) mice s
Metrics
Views
112 since deposited on 2017-04-27
111last week
Acq. date: 2025-11-12
Additional indexing
Creators (Authors)
- Gabriel, Sarah S
- Belge, Hendrica
- Gassama, Alkaly
- Debaix, Huguette
- Luciani, Alessandro
- Fehr, Thomas
- Devuyst, Olivier
Volume
Volume
Volume
91
Number
Number
Number
4
Page range/Item number
Page range/Item number
Page range/Item number
842
Page end
Page end
Page end
855
Item Type
Item Type
Item Type
Journal Article
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
English
Publication date
Publication date
Publication date
2017-04
Date available
Date available
Date available
2017-04-27
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
0085-2538
OA Status
OA Status
OA Status
Closed
Free Access at
Free Access at
Free Access at
DOI
Publisher DOI
Metrics
Views
112 since deposited on 2017-04-27
111last week
Acq. date: 2025-11-12
Closed
Loading...
No files available