Publication: Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy
Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy
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Costantino, S., Mengozzi, A., Velagapudi, S., Mohammed, S. A., Gorica, E., Akhmedov, A., Mongelli, A., Pugliese, N. R., Masi, S., Virdis, A., Hülsmeier, A., Matter, C. M., Hornemann, T., Melina, G., Ruschitzka, F., Luscher, T. F., & Paneni, F. (2023). Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy. Cardiovascular Diabetology, 22(1), 312. https://doi.org/10.1186/s12933-023-02057-2
Abstract
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Abstract
Background: Metabolic cardiomyopathy (MCM), characterized by intramyocardial lipid accumulation, drives the progression to heart failure with preserved ejection fraction (HFpEF). Although evidence suggests that the mammalian silent information regulator 1 (Sirt1) orchestrates myocardial lipid metabolism, it is unknown whether its exogenous administration could avoid MCM onset. We investigated whether chronic treatment with recombinant Sirt1 (rSirt1) could halt MCM progression.
Methods: db/db mice, an established model of MCM, were su
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Creators (Authors)
- Costantino, Sarah
- Mengozzi, Alessandro
- Velagapudi, Srividya
- Mohammed, Shafeeq Ahmed
- Gorica, Era
- Akhmedov, Alexander
- Mongelli, Alessia
- Pugliese, Nicola Riccardo
- Masi, Stefano
- Virdis, Agostino
- Hülsmeier, Andreas
- Matter, Christian Matthias
- Hornemann, Thorsten
- Melina, Giovanni
- Ruschitzka, Frank
- Luscher, Thomas Felix
- Paneni, Francesco
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Costantino, S., Mengozzi, A., Velagapudi, S., Mohammed, S. A., Gorica, E., Akhmedov, A., Mongelli, A., Pugliese, N. R., Masi, S., Virdis, A., Hülsmeier, A., Matter, C. M., Hornemann, T., Melina, G., Ruschitzka, F., Luscher, T. F., & Paneni, F. (2023). Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy. Cardiovascular Diabetology, 22(1), 312. https://doi.org/10.1186/s12933-023-02057-2
