The Brainbox-a tool to facilitate correlation of brain magnetic resonance imaging features to histopathology

Faigle, Wolfgang; Piccirelli, Marco; Hortobágyi, Tibor; Frontzek, Karl; Cannon, Amelia Elaine; Zürrer, Wolfgang Emanuel; Granberg, Tobias; Kulcsar, Zsolt; Ludersdorfer, Thomas; Frauenknecht, Katrin B M; Reimann, Regina; Ineichen, Benjamin Victor

doi:10.1093/braincomms/fcad307

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Faigle, W., Piccirelli, M., Hortobágyi, T., Frontzek, K., Cannon, A. E., Zürrer, W. E., Granberg, T., Kulcsar, Z., Ludersdorfer, T., Frauenknecht, K. B. M., Reimann, R., & Ineichen, B. V. (2023). The Brainbox-a tool to facilitate correlation of brain magnetic resonance imaging features to histopathology. Brain Communications, 5(6), fcad307. https://doi.org/10.1093/braincomms/fcad307

Abstract

Magnetic resonance imaging (MRI) has limitations in identifying underlying tissue pathology, which is relevant for neurological diseases such as multiple sclerosis, stroke or brain tumours. However, there are no standardized methods for correlating MRI features with histopathology. Thus, here we aimed to develop and validate a tool that can facilitate the correlation of brain MRI features to corresponding histopathology. For this, we designed the Brainbox, a waterproof and MRI-compatible 3D printed container with an integrated 3D coor