Publication: Hypoxia Reduces the Transcription of Fibrotic Markers in the Intestinal Mucosa
Hypoxia Reduces the Transcription of Fibrotic Markers in the Intestinal Mucosa
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Simmen, S., Maane, M., Rogler, S., Baebler, K., Lang, S., Cosin-Roger, J., Atrott, K., Frey-Wagner, I., Spielmann, P., Wenger, R. H., Weder, B., Zeitz, J., Vavricka, S. R., Rogler, G., de Vallière, C., Hausmann, M., & Ruiz, P. A. (2021). Hypoxia Reduces the Transcription of Fibrotic Markers in the Intestinal Mucosa. Inflammatory Intestinal Diseases, 6(2), 87–100. https://doi.org/10.1159/000513061
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Intestinal fibrosis, characterized by excessive deposition of extracellular matrix proteins, is a common and severe clinical complication of inflammatory bowel disease (IBD). However, the mechanisms underlying fibrosis remain elusive, and currently, there are limited effective pharmacologic treatments that target the development of fibrosis. Hypoxia is one of the key microenvironmental factors influencing intestinal inflammation and has been linked to fibrosis. In the present study, we sought to elucidate the impact of hypoxia on fib
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Simmen, S., Maane, M., Rogler, S., Baebler, K., Lang, S., Cosin-Roger, J., Atrott, K., Frey-Wagner, I., Spielmann, P., Wenger, R. H., Weder, B., Zeitz, J., Vavricka, S. R., Rogler, G., de Vallière, C., Hausmann, M., & Ruiz, P. A. (2021). Hypoxia Reduces the Transcription of Fibrotic Markers in the Intestinal Mucosa. Inflammatory Intestinal Diseases, 6(2), 87–100. https://doi.org/10.1159/000513061
