Publication: Responses of Ileal and Fecal Microbiota to Withdrawal of Pancreatic Enzyme Replacement Therapy in a Porcine Model of Exocrine Pancreatic Insufficiency
Responses of Ileal and Fecal Microbiota to Withdrawal of Pancreatic Enzyme Replacement Therapy in a Porcine Model of Exocrine Pancreatic Insufficiency
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Hankel, J., Mösseler, A., Hartung, C. B., Rath, S., Schulten, L., Visscher, C., Kamphues, J., & Vital, M. (2022). Responses of Ileal and Fecal Microbiota to Withdrawal of Pancreatic Enzyme Replacement Therapy in a Porcine Model of Exocrine Pancreatic Insufficiency. International Journal of Molecular Sciences, 23(19), 11700. https://doi.org/10.3390/ijms231911700
Abstract
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Abstract
Little is known regarding the interplay between microbiota and pancreas functions in humans as investigations are usually limited to distal sites, namely the analyses of fecal samples. The aim of this study was to investigate both ileal and fecal microbiota in response to pancreatic enzyme replacement therapy (PERT) in a porcine model of exocrine pancreatic insufficiency (EPI). PERT was stopped for ten days in ileo-cecal fistulated minipigs with experimentally induced EPI (n = 8) and ileal digesta as well as fecal samples were obtaine
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- Hankel, Julia
- Mösseler, Anne
- Hartung, C B
- Rath, Silke
- Schulten, Lisa
- Visscher, Christian
- Kamphues, Josef
- Vital, Marius
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Hankel, J., Mösseler, A., Hartung, C. B., Rath, S., Schulten, L., Visscher, C., Kamphues, J., & Vital, M. (2022). Responses of Ileal and Fecal Microbiota to Withdrawal of Pancreatic Enzyme Replacement Therapy in a Porcine Model of Exocrine Pancreatic Insufficiency. International Journal of Molecular Sciences, 23(19), 11700. https://doi.org/10.3390/ijms231911700
