Publication: Engineering, applications, and future perspectives of GPCR-based genetically encoded fluorescent indicators for neuromodulators
Engineering, applications, and future perspectives of GPCR-based genetically encoded fluorescent indicators for neuromodulators
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Rohner, V. L., Lamothe-Molina, P. J., & Patriarchi, T. (2024). Engineering, applications, and future perspectives of GPCR-based genetically encoded fluorescent indicators for neuromodulators. Journal of Neurochemistry, 168(3), 163–184. https://doi.org/10.1111/jnc.16045
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This review explores the evolving landscape of G-protein-coupled receptor (GPCR)-based genetically encoded fluorescent indicators (GEFIs), with a focus on their development, structural components, engineering strategies, and applications. We highlight the unique features of this indicator class, emphasizing the importance of both the sensing domain (GPCR structure and activation mechanism) and the reporting domain (circularly permuted fluorescent protein (cpFP) structure and fluorescence modulation). Further, we discuss indicator engi
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- Rohner, Valentin Lu
- Lamothe-Molina, Paul J
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Rohner, V. L., Lamothe-Molina, P. J., & Patriarchi, T. (2024). Engineering, applications, and future perspectives of GPCR-based genetically encoded fluorescent indicators for neuromodulators. Journal of Neurochemistry, 168(3), 163–184. https://doi.org/10.1111/jnc.16045
