Publication: Revisiting the putative role of heme as a trigger of inflammation
Revisiting the putative role of heme as a trigger of inflammation
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Vallelian, F., Schaer, C. A., Deuel, J. W., Ingoglia, G., Humar, R., Buehler, P. W., & Schaer, D. J. (2018). Revisiting the putative role of heme as a trigger of inflammation. Pharmacology Research & Perspectives, 6(2), e00392. https://doi.org/10.1002/prp2.392
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Abstract
Activation of the innate immune system by free heme has been proposed as one of the principal consequences of cell-free hemoglobin (Hb) exposure. Nonetheless, in the absence of infection, heme exposures within a hematoma, during hemolysis, or upon systemic administration of Hb (eg, as a Hb-based oxygen carrier) are typically not accompanied by uncontrolled inflammation, challenging the assumption that heme is a major proinflammatory mediator in vivo. Because of its hydrophobic nature, heme liberated from oxidized hemoglobin is rapidly
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- Vallelian, Florence
- Schaer, Christian A
- Deuel, Jeremy W
- Ingoglia, Giada
- Humar, Rok
- Buehler, Paul W
- Schaer, Dominik J
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Vallelian, F., Schaer, C. A., Deuel, J. W., Ingoglia, G., Humar, R., Buehler, P. W., & Schaer, D. J. (2018). Revisiting the putative role of heme as a trigger of inflammation. Pharmacology Research & Perspectives, 6(2), e00392. https://doi.org/10.1002/prp2.392
