Hybrid nanocomposite as a chest wall graft with improved integration by adipose-derived stem cells

Buschmann, Johanna; Yamada, Yoshito; Schulz-Schönhagen, Konstantin; Hess, Samuel C; Stark, Wendelin J; Opelz, Christine; Bürgisser, Gabriella Meier; Weder, Walter; Jungraithmayr, Wolfgang

doi:10.1038/s41598-019-47441-9

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Buschmann, J., Yamada, Y., Schulz-Schönhagen, K., Hess, S. C., Stark, W. J., Opelz, C., Bürgisser, G. M., Weder, W., & Jungraithmayr, W. (2019). Hybrid nanocomposite as a chest wall graft with improved integration by adipose-derived stem cells. Scientific Reports, 9, 10910. https://doi.org/10.1038/s41598-019-47441-9

Abstract

Surgery of the chest wall is potentially required to cover large defects after removal of malignant tumours. Usually, inert and non-degradable Gore-Tex serves to replace the missing tissue. However, novel biodegradable materials combined with stem cells are available that stimulate the healing. Based on poly-lactic-co-glycolic acid and amorphous calcium phosphate nanoparticles (PLGA/aCaP) and pure PLGA, a dual layer biodegradable hybrid nanocomposite was generated. Mouse adipose-derived stem cells were cultered on electrospun disks (