Publication: The B1 H + -ATPase ( Atp6v1b1 ) Subunit in Non-Type-A Intercalated Cells is Required for Driving Pendrin Activity and the Renal Defence Against Alkalosis
The B1 H + -ATPase ( Atp6v1b1 ) Subunit in Non-Type-A Intercalated Cells is Required for Driving Pendrin Activity and the Renal Defence Against Alkalosis
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Bourgeois, S., Kovacikova, J., Bugarski, M., Bettoni, C., Gehring, N., Hall, A., & Wagner, C. A. (2024). The B1 H + -ATPase ( Atp6v1b1 ) Subunit in Non-Type-A Intercalated Cells is Required for Driving Pendrin Activity and the Renal Defence Against Alkalosis. Journal of the American Society of Nephrology (JASN), 35(1), 7–21. https://doi.org/10.1681/ASN.0000000000000259
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BACKGROUND: Non-type-A intercalated cells (IC) in the collecting duct system express the luminal Cl - /HCO 3- exchanger pendrin and apical and/or basolateral H + -ATPases containing the B1 subunit isoform. Non-type-A ICs excrete bicarbonate during metabolic alkalosis. Mutations in the B1 subunit (ATP6V1B1) cause distal renal tubular acidosis due to its role in acid secretory type-A ICs. The function of B1 in non-type-A ICs has remained elusive. METHODS: We examined responses of Atp6v1b1-/- and Atp6v1b1+/+ mice to an alkali load and to
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Bourgeois, S., Kovacikova, J., Bugarski, M., Bettoni, C., Gehring, N., Hall, A., & Wagner, C. A. (2024). The B1 H + -ATPase ( Atp6v1b1 ) Subunit in Non-Type-A Intercalated Cells is Required for Driving Pendrin Activity and the Renal Defence Against Alkalosis. Journal of the American Society of Nephrology (JASN), 35(1), 7–21. https://doi.org/10.1681/ASN.0000000000000259