Publication: Thiol- and Disulfide-Containing Vancomycin Derivatives Against Bacterial Resistance and Biofilm Formation
Thiol- and Disulfide-Containing Vancomycin Derivatives Against Bacterial Resistance and Biofilm Formation
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Shchelik, I. S., & Gademann, K. (2021). Thiol- and Disulfide-Containing Vancomycin Derivatives Against Bacterial Resistance and Biofilm Formation. ACS Medicinal Chemistry Letters, 12(12), 1898–1904. https://doi.org/10.1021/acsmedchemlett.1c00455
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Antibiotic-resistant and biofilm-associated infections constitute a rapidly growing issue. Use of the last resort antibiotic vancomycin is under threat, due to the increasing appearance of vancomycin resistant bacteria as well as the formation of biofilms. Herein, we report a series of novel vancomycin derivatives carrying thiol- and disulfide-containing moieties. The new compounds exhibited enhanced antibacterial activity against a broad range of bacterial strains, including vancomycin resistant microbes and Gram-negative bacteria. M
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- Shchelik, Inga S
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Shchelik, I. S., & Gademann, K. (2021). Thiol- and Disulfide-Containing Vancomycin Derivatives Against Bacterial Resistance and Biofilm Formation. ACS Medicinal Chemistry Letters, 12(12), 1898–1904. https://doi.org/10.1021/acsmedchemlett.1c00455
