Publication: Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5
Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5
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Radom, F., Vonrhein, C., Mittl, P. R. E., & Plückthun, A. (2021). Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 77(Pt 7), 192–201. https://doi.org/10.1107/S2053230X21006002
Abstract
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The members of the human epidermal growth factor receptor (HER) family are among the most intensely studied oncological targets. HER3 (ErbB3), which had long been neglected, has emerged as a key oncogene, regulating the activity of other receptors and being involved in progression and tumor escape in multiple types of cancer. Designed ankyrin-repeat proteins (DARPins) serve as antibody mimetics that have proven to be useful in the clinic, in diagnostics and in research. DARPins have previously been selected against EGFR (HER1), HER2 a
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Creators (Authors)
- Radom, Filip
- Vonrhein, Clemens
- Mittl, Peer R E
- Plückthun, Andreas
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Citations
Radom, F., Vonrhein, C., Mittl, P. R. E., & Plückthun, A. (2021). Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 77(Pt 7), 192–201. https://doi.org/10.1107/S2053230X21006002
