Publication: Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils
Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils
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Wicki, S., Gurzeler, U., Wong, W. W.-L., Jost, P. J., Bachmann, D., & Kaufmann, T. (2016). Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils. Cell Death and Disease, 7(10), e2422. https://doi.org/10.1038/cddis.2016.311
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Neutrophils are essential players in the first-line defense against invading bacteria and fungi. Besides its antiapoptotic role, the inhibitor of apoptosis protein (IAP) family member X-linked IAP (XIAP) has been shown to regulate innate immune signaling. Whereas the role of XIAP in innate signaling pathways is derived mostly from work in macrophages and dendritic cells, it is not known if and how XIAP contributes to these pathways in neutrophils. Here we show that in response to bacterial lipopolysaccharides (LPS), mouse neutrophils
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- Wicki, S
- Gurzeler, U
- Wong, W Wei-Lynn
- Jost, P J
- Bachmann, D
- Kaufmann, T
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Wicki, S., Gurzeler, U., Wong, W. W.-L., Jost, P. J., Bachmann, D., & Kaufmann, T. (2016). Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils. Cell Death and Disease, 7(10), e2422. https://doi.org/10.1038/cddis.2016.311
