Publication: The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis
Date
Date
Date
2022
Journal Article
Published version
Abstract
Abstract
Abstract
The accurate repair of DNA double-strand breaks (DSBs), highly toxic DNA lesions, is crucial for genome integrity and is tightly regulated during the cell cycle. In mitosis, cells inactivate DSB repair in favor of a tethering mechanism that stabilizes broken chromosomes until they are repaired in the subsequent cell cycle phases. How this is achieved mechanistically is not yet understood, but the adaptor protein TOPBP1 is critically implicated in this process. Here, we identify CIP2A as a TOPBP1-interacting protein that regulates TOPB
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59 since deposited on 2023-02-14
Acq. date: 2025-11-13
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76 since deposited on 2023-02-14
Acq. date: 2025-11-13
Additional indexing
Creators (Authors)
- de Marco Zompit, Mara
- Esteban, Mònica Torres
- Mooser, Clémence
- Adam, Salomé
- Rossi, Silvia Emma
- Jeanrenaud, Alain
- Leimbacher, Pia-Amata
- Fink, Daniel
- Shorrocks, Ann-Marie K
- Blackford, Andrew N
- Durocher, Daniel
- Stucki, Manuel
Volume
Volume
Volume
13
Number
Number
Number
1
Page range/Item number
Page range/Item number
Page range/Item number
4143
Item Type
Item Type
Item Type
Journal Article
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
English
Publication date
Publication date
Publication date
2022-07-16
Date available
Date available
Date available
2023-02-14
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
2041-1723
OA Status
OA Status
OA Status
Gold
Free Access at
Free Access at
Free Access at
Pubmed ID
Publisher DOI
Metrics
Downloads
59 since deposited on 2023-02-14
Acq. date: 2025-11-13
Views
76 since deposited on 2023-02-14
Acq. date: 2025-11-13
Gold Open Access
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Files
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Files
Files
Files
Files available to download:2