Profiling walking dysfunction in multiple sclerosis: characterisation, classification and progression over time

Filli, Linard; Sutter, Tabea; Easthope, Christopher S; Killeen, Tim; Meyer, Christian; Reuter, Katja; Lörincz, Lilla; Bolliger, Marc; Weller, Michael; Curt, Armin; Straumann, Dominik; Linnebank, Michael; Zörner, Björn

doi:10.1038/s41598-018-22676-0

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Filli, L., Sutter, T., Easthope, C. S., Killeen, T., Meyer, C., Reuter, K., Lörincz, L., Bolliger, M., Weller, M., Curt, A., Straumann, D., Linnebank, M., & Zörner, B. (2018). Profiling walking dysfunction in multiple sclerosis: characterisation, classification and progression over time. Scientific Reports, 8, 4984. https://doi.org/10.1038/s41598-018-22676-0

Abstract

Gait dysfunction is a common and relevant symptom in multiple sclerosis (MS). This study aimed to profile gait pathology in gait-impaired patients with MS using comprehensive 3D gait analysis and clinical walking tests. Thirty-seven patients with MS walked on the treadmill at their individual, sustainable speed while 20 healthy control subjects walked at all the different patient's paces, allowing for comparisons independent of walking velocity. Kinematic analysis revealed pronounced restrictions in knee and ankle joint excursion, inc