Publication: Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys
Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys
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Le Hir, M., Hegyi, I., Cueni-Loffing, D., Loffing, J., & Kaissling, B. (2005). Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys. Histochemistry and Cell Biology, 123(4–5), 335–346. https://doi.org/10.1007/s00418-005-0788-z
Abstract
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Fibrosis is considered as a central factor in the loss of renal function in chronic kidney diseases. The origin of fibroblasts and myofibroblasts that accumulate in the interstitium of the diseased kidney is still a matter of debate. It has been shown that accumulation of myofibroblasts in inflamed and fibrotic kidneys is associated with upregulation of fibroblast-specific protein1 (FSP1, S100A4), not only in the renal interstitium but also in the injured renal epithelia. The tubular expression of FSP1 has been taken as evidence of my
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- Le Hir, Michel
- Hegyi, Ivan
- Cueni-Loffing, Dominique
- Loffing, Johannes
- Kaissling, Brigitte
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Citations
Le Hir, M., Hegyi, I., Cueni-Loffing, D., Loffing, J., & Kaissling, B. (2005). Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys. Histochemistry and Cell Biology, 123(4–5), 335–346. https://doi.org/10.1007/s00418-005-0788-z
