Publication: Impact of suboptimal APOBEC3G neutralization on the emergence of HIV drug resistance in humanized mice
Impact of suboptimal APOBEC3G neutralization on the emergence of HIV drug resistance in humanized mice
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Hernandez, M. M., Fahrny, A., Jayaprakash, A., Gers-Huber, G., Dillon-White, M., Audigé, A., Mulder, L. C. F., Sachidanandam, R., Speck, R. F., & Simon, V. (2019). Impact of suboptimal APOBEC3G neutralization on the emergence of HIV drug resistance in humanized mice. Journal of Virology, 94(5), 0–0. https://doi.org/10.1128/JVI.01543-19
Abstract
Abstract
Abstract
HIV diversification facilitates immune escape and complicates antiretroviral therapy. In this study, we take advantage of a humanized mouse model to probe the contribution of APOBEC3 mutagenesis to viral evolution. Humanized mice were infected with isogenic HIV molecular clones (HIV-WT, HIV-45G, HIV-ΔSLQ) that differ in their ability to counteract APOBEC3G (A3G). Infected mice remained naïve or were treated with the RT inhibitor lamivudine (3TC). Viremia, emergence of drug resistant variants and quasispecies diversification in the pla
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- Hernandez, Matthew M
- Fahrny, Audrey
- Jayaprakash, Anitha
- Gers-Huber, Gustavo
- Dillon-White, Marsha
- Audigé, Annette
- Mulder, Lubbertus C F
- Sachidanandam, Ravi
- Speck, Roberto F
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Hernandez, M. M., Fahrny, A., Jayaprakash, A., Gers-Huber, G., Dillon-White, M., Audigé, A., Mulder, L. C. F., Sachidanandam, R., Speck, R. F., & Simon, V. (2019). Impact of suboptimal APOBEC3G neutralization on the emergence of HIV drug resistance in humanized mice. Journal of Virology, 94(5), 0–0. https://doi.org/10.1128/JVI.01543-19
