Publication: Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease
Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease
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Luo, J., Thomassen, J. Q., Bellenguez, C., Grenier-Boley, B., de Rojas, I., Castillo, A., Parveen, K., Küçükali, F., Nicolas, A., Peters, O., Schneider, A., Dichgans, M., Rujescu, D., Scherbaum, N., Jürgen, D., Riedel-Heller, S., Hausner, L., Porcel, L. M., Düzel, E., … et al. (2023). Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease. JAMA Network Open, 6(5), e2313734. https://doi.org/10.1001/jamanetworkopen.2023.13734
Abstract
Abstract
Abstract
Importance: An estimated 40% of dementia is potentially preventable by modifying 12 risk factors throughout the life course. However, robust evidence for most of these risk factors is lacking. Effective interventions should target risk factors in the causal pathway to dementia.
Objective: To comprehensively disentangle potentially causal aspects of modifiable risk factors for Alzheimer disease (AD) to inspire new drug targeting and improved prevention.
Design, setting, and participants: This genetic association study was conducted u
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Creators (Authors)
- Luo, Jiao
- Thomassen, Jesper Qvist
- Bellenguez, Céline
- Grenier-Boley, Benjamin
- de Rojas, Itziar
- Castillo, Atahualpa
- Parveen, Kayenat
- Küçükali, Fahri
- Nicolas, Aude
- Peters, Oliver
- Schneider, Anja
- Dichgans, Martin
- Rujescu, Dan
- Scherbaum, Norbert
- Jürgen, Deckert
- Riedel-Heller, Steffi
- Hausner, Lucrezia
- Porcel, Laura Molina
- Düzel, Emrah
- Grimmer, Timo
- Wiltfang, Jens
- Heilmann-Heimbach, Stefanie
- Moebus, Susanne
- Tegos, Thomas
- Scarmeas, Nikolaos
- Clarimon, Jordi
- Moreno, Fermin
- Pérez-Tur, Jordi
- Bullido, María J
- Popp, Julius
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Luo, J., Thomassen, J. Q., Bellenguez, C., Grenier-Boley, B., de Rojas, I., Castillo, A., Parveen, K., Küçükali, F., Nicolas, A., Peters, O., Schneider, A., Dichgans, M., Rujescu, D., Scherbaum, N., Jürgen, D., Riedel-Heller, S., Hausner, L., Porcel, L. M., Düzel, E., … et al. (2023). Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease. JAMA Network Open, 6(5), e2313734. https://doi.org/10.1001/jamanetworkopen.2023.13734
