Tracking Adenovirus DNA in Entry and Replication Provides Insight into Virion Uncoating and Assembly

Abstract

Adenoviruses (AdV) are double-stranded DNA (dsDNA) viruses with an icosahedral proteinaceous capsid lacking a lipid envelope. AdV initiate infection by traversing from the cell surface to the nucleus and release their genome into the nucleus at the nuclear pore complex (NPC). The proteins and RNA encoded in the viral DNA (vDNA) counteract the host defense machinery and activate viral gene expression, genome replication and progeny formation. During the infection cycle, the vDNA undergoes significant rearrangements. Although some of th Show more