Publication: Early postnatal amylin treatment enhances hypothalamic leptin signaling and neural development in the selectively bred diet-induced obese rat
Early postnatal amylin treatment enhances hypothalamic leptin signaling and neural development in the selectively bred diet-induced obese rat
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Johnson, M. D., Bouret, S. G., Dunn-Meynell, A. A., Boyle, C. N., Lutz, T. A., & Levin, B. E. (2016). Early postnatal amylin treatment enhances hypothalamic leptin signaling and neural development in the selectively bred diet-induced obese rat. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 311(6), R1032–R1044. https://doi.org/10.1152/ajpregu.00326.2016
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Selectively bred diet-induced obese (DIO) rats become obese on a high-fat diet and are leptin resistant before becoming obese. Compared with diet-resistant (DR) neonates, DIO neonates have impaired leptin-dependent arcuate (ARC) neuropeptide Y/agouti-related peptide (NPY/AgRP) and α-melanocyte-stimulating hormone (α-MSH; from proopiomelanocortin (POMC) neurons) axon outgrowth to the paraventricular nucleus (PVN). Using phosphorylation of STAT3 (pSTAT3) as a surrogate, we show that reduced DIO ARC leptin signaling develops by postnatal
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- Johnson, Miranda D
- Bouret, Sebastien G
- Dunn-Meynell, Ambrose A
- Boyle, Christina N
- Lutz, Thomas A
- Levin, Barry E
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Johnson, M. D., Bouret, S. G., Dunn-Meynell, A. A., Boyle, C. N., Lutz, T. A., & Levin, B. E. (2016). Early postnatal amylin treatment enhances hypothalamic leptin signaling and neural development in the selectively bred diet-induced obese rat. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 311(6), R1032–R1044. https://doi.org/10.1152/ajpregu.00326.2016
