Publication: Recombinant rotaviruses rescued by reverse genetics reveal the role of NSP5 hyperphosphorylation in the assembly of viral factories
Recombinant rotaviruses rescued by reverse genetics reveal the role of NSP5 hyperphosphorylation in the assembly of viral factories
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Papa, G., Venditti, L., Arnoldi, F., Schraner, E. M., Potgieter, C., Borodavka, A., Eichwald, C., & Burrone, O. R. (2019). Recombinant rotaviruses rescued by reverse genetics reveal the role of NSP5 hyperphosphorylation in the assembly of viral factories. Journal of Virology, 94, e01110–e01119. https://doi.org/10.1128/jvi.01110-19
Abstract
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Abstract
Rotavirus (RV) replicates in round-shaped cytoplasmic viral factories, although how they assemble remains unknown. During RV infection, NSP5 undergoes hyperphosphorylation, which is primed by the phosphorylation of a single serine residue. The role of this posttranslational modification in the formation of viroplasms and its impact on virus replication remain obscure. Here, we investigated the role of NSP5 during RV infection by taking advantage of a modified fully tractable reverse-genetics system. A trans-complementing cell line sta
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- Papa, Guido
- Venditti, Luca
- Arnoldi, Francesca
- Schraner, Elisabeth M
- Potgieter, Christiaan
- Borodavka, Alexander
- Eichwald, Catherine
- Burrone, Oscar R
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Papa, G., Venditti, L., Arnoldi, F., Schraner, E. M., Potgieter, C., Borodavka, A., Eichwald, C., & Burrone, O. R. (2019). Recombinant rotaviruses rescued by reverse genetics reveal the role of NSP5 hyperphosphorylation in the assembly of viral factories. Journal of Virology, 94, e01110–e01119. https://doi.org/10.1128/jvi.01110-19
