Publication: Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1
Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1
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Nischang, M., Sutmuller, R., Gers-Huber, G., Audigé, A., Li, D., Rochat, M.-A., Baenziger, S., Hofer, U., Schlaepfer, E., Regenass, S., Amssoms, K., Stoops, B., Van Cauwenberge, A., Boden, D., Kraus, G., & Speck, R. F. (2012). Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1. PLoS ONE, 7(6), e38853. https://doi.org/10.1371/journal.pone.0038853
Abstract
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Abstract
BACKGROUND: Humanized mice generate a lymphoid system of human origin subsequent to transplantation of human CD34+ cells and thus are highly susceptible to HIV infection. Here we examined the efficacy of antiretroviral treatment (ART) when added to food pellets, and of long-acting (LA) antiretroviral compounds, either as monotherapy or in combination. These studies shall be inspiring for establishing a gold standard of ART, which is easy to administer and well supported by the mice, and for subsequent studies such as latency. Furtherm
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Creators (Authors)
- Nischang, Marc
- Sutmuller, Roger
- Gers-Huber, Gustavo
- Audigé, Annette
- Li, Duo
- Rochat, Mary-Aude
- Baenziger, Stefan
- Hofer, Ursula
- Schlaepfer, Erika
- Regenass, Stephan
- Amssoms, Katie
- Stoops, Bart
- Van Cauwenberge, Anja
- Boden, Daniel
- Kraus, Guenter
- Speck, Roberto F
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Nischang, M., Sutmuller, R., Gers-Huber, G., Audigé, A., Li, D., Rochat, M.-A., Baenziger, S., Hofer, U., Schlaepfer, E., Regenass, S., Amssoms, K., Stoops, B., Van Cauwenberge, A., Boden, D., Kraus, G., & Speck, R. F. (2012). Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1. PLoS ONE, 7(6), e38853. https://doi.org/10.1371/journal.pone.0038853
