Publication: Generation of a Recombinant Gag Virus-Like-Particle Panel for the Evaluation of p24 Antigen Detection by Diagnostic HIV Test
Generation of a Recombinant Gag Virus-Like-Particle Panel for the Evaluation of p24 Antigen Detection by Diagnostic HIV Test
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Vetter, B. N., Orlowski, V., Fransen, K., Niederhauser, C., Aubert, V., Brandenberger, M., Ciardo, D., Dollenmaier, G., Klimkait, T., Regenass, S., Schmid, P., Schottstedt, V., Suter-Riniker, F., Yerly, S., Shah, C., Böni, J., & Schüpbach, J. (2014). Generation of a Recombinant Gag Virus-Like-Particle Panel for the Evaluation of p24 Antigen Detection by Diagnostic HIV Test. PLoS ONE, 9(10), e111552–e111552. https://doi.org/10.1371/journal.pone.0111552
Abstract
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Abstract
Background: Detection of HIV-1 p24 antigen permits early identification of primary HIV infection and timely intervention to limit further spread of the infection. Principally, HIV screening should equally detect all viral variants, but reagents for a standardised test evaluation are limited. Therefore, we aimed to create an inexhaustible panel of diverse HIV-1 p24 antigens. Methods: We generated a panel of 43 recombinantly expressed virus-like particles (VLPs), containing the structural Gag proteins of HIV-1 subtypes A-H and circulati
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Creators (Authors)
- Vetter, B N
- Orlowski, V
- Fransen, K
- Niederhauser, C
- Aubert, V
- Brandenberger, M
- Ciardo, D
- Dollenmaier, G
- Klimkait, T
- Regenass, S
- Schmid, P
- Schottstedt, V
- Suter-Riniker, F
- Yerly, S
- Shah, C
- Böni, J
- Schüpbach, J
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Vetter, B. N., Orlowski, V., Fransen, K., Niederhauser, C., Aubert, V., Brandenberger, M., Ciardo, D., Dollenmaier, G., Klimkait, T., Regenass, S., Schmid, P., Schottstedt, V., Suter-Riniker, F., Yerly, S., Shah, C., Böni, J., & Schüpbach, J. (2014). Generation of a Recombinant Gag Virus-Like-Particle Panel for the Evaluation of p24 Antigen Detection by Diagnostic HIV Test. PLoS ONE, 9(10), e111552–e111552. https://doi.org/10.1371/journal.pone.0111552
