Direct transplantation of native pericytes from adipose tissue: A new perspective to stimulate healing in critical size bone defects

König, Matthias A; Canepa, Daisy D; Cadosch, Dieter; Casanova, Elisa; Heinzelmann, Michael; Rittirsch, Daniel; Plecko, Michael; Hemmi, Sonja; Simmen, Hans-Peter; Cinelli, Paolo; Wanner, Guido A

doi:10.1016/j.jcyt.2015.10.002

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König, M. A., Canepa, D. D., Cadosch, D., Casanova, E., Heinzelmann, M., Rittirsch, D., Plecko, M., Hemmi, S., Simmen, H.-P., Cinelli, P., & Wanner, G. A. (2016). Direct transplantation of native pericytes from adipose tissue: A new perspective to stimulate healing in critical size bone defects. Cytotherapy, 18, 41–52. https://doi.org/10.1016/j.jcyt.2015.10.002

Abstract

BACKGROUND AIMS Fractures with a critical size bone defect (e.g., open fracture with segmental bone loss) are associated with high rates of delayed union and non-union. The prevention and treatment of these complications remain a serious issue in trauma and orthopaedic surgery. Autologous cancellous bone grafting is a well-established and widely used technique. However, it has drawbacks related to availability, increased morbidity and insufficient efficacy. Mesenchymal stromal cells can potentially be used to improve fracture healing