Publication: Novel Mechanisms of Control of Replication Fork Plasticity by Nuclear Dynamics
Novel Mechanisms of Control of Replication Fork Plasticity by Nuclear Dynamics
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Cherdyntseva, V. (2024). Novel Mechanisms of Control of Replication Fork Plasticity by Nuclear Dynamics. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-264185
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Replication stress (RS), a term that collectively refers to slowing down or stalling of the replication forks, is a recognized causative event in tumorigenesis that has been exploited as a cancer chemotherapeutic strategy to limit the uncontrolled proliferation of cancer cells. A battery of cellular mechanisms has evolved to cope with RS in order to ensure the fidelity of DNA replication and genome stability. Among them, replication fork reversal (RFR) -i.e. the transient remodeling of a replication fork from a 3-way to a 4-way juncti
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Cherdyntseva, V. (2024). Novel Mechanisms of Control of Replication Fork Plasticity by Nuclear Dynamics. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-264185
