Publication: Mitotic Index Thresholds Do Not Predict Clinical Outcome for IDH-Mutant Astrocytoma
Mitotic Index Thresholds Do Not Predict Clinical Outcome for IDH-Mutant Astrocytoma
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Yoda, R. A., Marxen, T., Longo, L., Ene, C., Wirsching, H.-G., Keene, C. D., Holland, E. C., & Cimino, P. J. (2019). Mitotic Index Thresholds Do Not Predict Clinical Outcome for IDH-Mutant Astrocytoma. Journal of Neuropathology and Experimental Neurology, 78, 1002–1010. https://doi.org/10.1093/jnen/nlz082
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Current histological grading recommendations for isocitrate dehydrogenase (IDH)-mutant astrocytoma are imprecise and not reliably predictive of patient outcome, while somatic copy number alterations are emerging as important prognostic biomarkers. One explanation for this relative underperformance of histological grading is that current criteria to distinguish World Health Organization (WHO) grade III anaplastic astrocytomas from lower-grade diffuse astrocytomas (WHO grade II) are vague ("increased mitotic activity"). This qualitative
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- Yoda, Rebecca A
- Marxen, Troy
- Longo, Lauren
- Ene, Chibawanye
- Wirsching, Hans-Georg
- Keene, C Dirk
- Holland, Eric C
- Cimino, Patrick J
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Yoda, R. A., Marxen, T., Longo, L., Ene, C., Wirsching, H.-G., Keene, C. D., Holland, E. C., & Cimino, P. J. (2019). Mitotic Index Thresholds Do Not Predict Clinical Outcome for IDH-Mutant Astrocytoma. Journal of Neuropathology and Experimental Neurology, 78, 1002–1010. https://doi.org/10.1093/jnen/nlz082
