Publication: Interleukin-2: biology, design and application
Interleukin-2: biology, design and application
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Arenas-Ramirez, N., Woytschak, J., & Boyman, O. (2015). Interleukin-2: biology, design and application. Trends in Immunology, 36(12), 763–777. https://doi.org/10.1016/j.it.2015.10.003
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Interleukin-2 (IL-2) exerts crucial functions during immune homeostasis via its effects on regulatory T (Treg) cells, and the optimizing and fine-tuning of effector lymphocyte responses. Thus, somewhat paradoxically, low doses of recombinant IL-2 have been used for Treg cell-based immunosuppressive strategies against immune pathologies, while high-dose IL-2 has shown some success in stimulating anti-tumor immune responses. Recent studies of the functional, biophysical and structural characteristics of IL-2 have led to the generation o
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- Arenas-Ramirez, Natalia
- Woytschak, Janine
- Boyman, Onur
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Arenas-Ramirez, N., Woytschak, J., & Boyman, O. (2015). Interleukin-2: biology, design and application. Trends in Immunology, 36(12), 763–777. https://doi.org/10.1016/j.it.2015.10.003
