Publication: Exhaustive analysis of a genotype space comprising 1015 central carbon metabolisms reveals an organization conducive to metabolic innovation
Exhaustive analysis of a genotype space comprising 1015 central carbon metabolisms reveals an organization conducive to metabolic innovation
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Hosseini, S.-R., Barve, A., & Wagner, A. (2015). Exhaustive analysis of a genotype space comprising 1015 central carbon metabolisms reveals an organization conducive to metabolic innovation. PLoS Computational Biology, 11(8), e1004329. https://doi.org/10.1371/journal.pcbi.1004329
Abstract
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Abstract
All biological evolution takes place in a space of possible genotypes and their phenotypes. The structure of this space defines the evolutionary potential and limitations of an evolving system. Metabolism is one of the most ancient and fundamental evolving systems, sustaining life by extracting energy from extracellular nutrients. Here we study metabolism's potential for innovation by analyzing an exhaustive genotype-phenotype map for a space of 10(15) metabolisms that encodes all possible subsets of 51 reactions in central carbon met
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- Hosseini, Sayed-Rzgar
- Barve, Aditya
- Wagner, Andreas
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Citations
Hosseini, S.-R., Barve, A., & Wagner, A. (2015). Exhaustive analysis of a genotype space comprising 1015 central carbon metabolisms reveals an organization conducive to metabolic innovation. PLoS Computational Biology, 11(8), e1004329. https://doi.org/10.1371/journal.pcbi.1004329
