Publication: Deletion of Both Rab-GTPase-Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport
Deletion of Both Rab-GTPase-Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport
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Chadt, A., Immisch, A., de Wendt, C., Springer, C., Zhou, Z., Stermann, T., Holman, G. D., Loffing-Cueni, D., Loffing, J., Joost, H.-G., & Al-Hasani, H. (2015). Deletion of Both Rab-GTPase-Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport. Diabetes, 64(3), 746–759. https://doi.org/10.2337/db14-0368
Abstract
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Abstract
The Rab-GTPase-activating proteins TBC1D1 and TBC1D4 (AS160) were previously shown to regulate GLUT4 translocation in response to activation of AKT and AMP-dependent kinase. However, knockout mice lacking either Tbc1d1 or Tbc1d4 displayed only partially impaired insulin-stimulated glucose uptake in fat and muscle tissue. The aim of this study was to determine the impact of the combined inactivation of Tbc1d1 and Tbc1d4 on glucose metabolism in double-deficient (D1/4KO) mice. D1/4KO mice displayed normal fasting glucose concentrations
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- Chadt, Alexandra
- Immisch, Anja
- de Wendt, Christian
- Springer, Christian
- Zhou, Zhou
- Stermann, Torben
- Holman, Geoffrey D
- Loffing-Cueni, Dominique
- Loffing, Johannes
- Joost, Hans-Georg
- Al-Hasani, Hadi
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Chadt, A., Immisch, A., de Wendt, C., Springer, C., Zhou, Z., Stermann, T., Holman, G. D., Loffing-Cueni, D., Loffing, J., Joost, H.-G., & Al-Hasani, H. (2015). Deletion of Both Rab-GTPase-Activating Proteins TBC1D1 and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport. Diabetes, 64(3), 746–759. https://doi.org/10.2337/db14-0368
