Publication: Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
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Le Guen, Y., Luo, G., Ambati, A., Damotte, V., Jansen, I., Yu, E., Nicolas, A., de Rojas, I., Peixoto Leal, T., Miyashita, A., Bellenguez, C., Lian, M. M., Parveen, K., Morizono, T., Park, H., Grenier-Boley, B., Naito, T., Küçükali, F., Talyansky, S. D., … Popp, J. (2023). Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes. Proceedings of the National Academy of Sciences of the United States of America, 120, e2302720120. https://doi.org/10.1073/pnas.2302720120
Abstract
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Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson's disease (PD) and Alzheimer's disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB104 subtypes best accounted for the association, strongest with HLA-DRB104:04 and HLA-DRB104:07, and intermediary with HLA-DRB104:01 and HLA-DRB1*04:03. The same signal was as
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- Le Guen, Yann
- Luo, Guo
- Ambati, Aditya
- Damotte, Vincent
- Jansen, Iris
- Yu, Eric
- Nicolas, Aude
- de Rojas, Itziar
- Peixoto Leal, Thiago
- Miyashita, Akinori
- Bellenguez, Céline
- Lian, Michelle Mulan
- Parveen, Kayenat
- Morizono, Takashi
- Park, Hyeonseul
- Grenier-Boley, Benjamin
- Naito, Tatsuhiko
- Küçükali, Fahri
- Talyansky, Seth D
- Yogeshwar, Selina Maria
- Sempere, Vicente
- Satake, Wataru
- Alvarez, Victoria
- Arosio, Beatrice
- Belloy, Michael E
- Benussi, Luisa
- Boland, Anne
- Borroni, Barbara
- Bullido, María J
- Caffarra, Paolo
- Popp, Julius
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Le Guen, Y., Luo, G., Ambati, A., Damotte, V., Jansen, I., Yu, E., Nicolas, A., de Rojas, I., Peixoto Leal, T., Miyashita, A., Bellenguez, C., Lian, M. M., Parveen, K., Morizono, T., Park, H., Grenier-Boley, B., Naito, T., Küçükali, F., Talyansky, S. D., … Popp, J. (2023). Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes. Proceedings of the National Academy of Sciences of the United States of America, 120, e2302720120. https://doi.org/10.1073/pnas.2302720120
