Publication: Herpes simplex virus 1 induces de novo phospholipid synthesis
Herpes simplex virus 1 induces de novo phospholipid synthesis
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Sutter, E., de Oliveira, A. P., Tobler, K., Schraner, E. M., Sonda, S., Kaech, A., Lucas, M. S., Ackermann, M., & Wild, P. (2012). Herpes simplex virus 1 induces de novo phospholipid synthesis. Virology, 429(2), 124–135. https://doi.org/10.1016/j.virol.2012.04.004
Abstract
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Abstract
Herpes simplex virus type 1 capsids bud at nuclear membranes and Golgi membranes acquiring an envelope composed of phospholipids. Hence, we measured incorporation of phospholipid precursors into these membranes, and quantified changes in size of cellular compartments by morphometric analysis. Incorporation of [³H]-choline into both nuclear and cytoplasmic membranes was significantly enhanced upon infection. [³H]-choline was also part of isolated virions even grown in the presence of brefeldin A. Nuclei expanded early in infection. The
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- Sutter, Esther
- de Oliveira, Anna Paula
- Tobler, Kurt
- Schraner, Elisabeth M
- Sonda, Sabrina
- Kaech, Andres
- Lucas, Miriam S
- Ackermann, M
- Wild, Peter
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Sutter, E., de Oliveira, A. P., Tobler, K., Schraner, E. M., Sonda, S., Kaech, A., Lucas, M. S., Ackermann, M., & Wild, P. (2012). Herpes simplex virus 1 induces de novo phospholipid synthesis. Virology, 429(2), 124–135. https://doi.org/10.1016/j.virol.2012.04.004
