Publication: The antibacterial substance taurolidine exhibits anti-neoplastic action based on a mixed type of programmed cell death
The antibacterial substance taurolidine exhibits anti-neoplastic action based on a mixed type of programmed cell death
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Stendel, R., Cetina Biefer, H. R., Dékány, G. M., Kubota, H., Münz, C., Wang, S., Mohler, H., Yonekawa, Y., & Frei, K. (2009). The antibacterial substance taurolidine exhibits anti-neoplastic action based on a mixed type of programmed cell death. Autophagy, 5(2), 194–210. https://doi.org/10.4161/auto.5.2.7404
Abstract
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The antibacterial amino-acid derivative taurolidine (TAU) has been recently shown to exhibit anti-neoplastic activity based on a mechanism, which is still unknown in detail. Cytotoxicity and clonogenic assays were performed and the impact of apoptosis modulators, a radical scavenger, autophagy inhibitors, silencing of apoptosis inducing actor (AIF) and cytochrome-c (Cyt-C) by siRNA, and knockdown of autophagy related genes were evaluated in vitro. The intracellular ATP-content, release of AIF and Cyt-C, and DNA-laddering were investig
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- Stendel, R
- Cetina Biefer, H R
- Dékány, G M
- Kubota, H
- Münz, C
- Wang, S
- Mohler, H
- Yonekawa, Y
- Frei, K
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Stendel, R., Cetina Biefer, H. R., Dékány, G. M., Kubota, H., Münz, C., Wang, S., Mohler, H., Yonekawa, Y., & Frei, K. (2009). The antibacterial substance taurolidine exhibits anti-neoplastic action based on a mixed type of programmed cell death. Autophagy, 5(2), 194–210. https://doi.org/10.4161/auto.5.2.7404
