Publication: Convergent network effects along the axis of gene expression during prostate cancer progression
Convergent network effects along the axis of gene expression during prostate cancer progression
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Charmpi, K., Guo, T., Zhong, Q., Wagner, U., Sun, R., Toussaint, N. C., Fritz, C. E., Yuan, C., Chen, H., Rupp, N. J., Christiansen, A., Rutishauser, D., Rüschoff, J. H., Fankhauser, C., Saba, K., Poyet, C., Hermanns, T., Oehl, K., Moore, A. L., … Beyer, A. (2020). Convergent network effects along the axis of gene expression during prostate cancer progression. Genome Biology, 21, 302. https://doi.org/10.1186/s13059-020-02188-9
Abstract
Abstract
Abstract
BACKGROUND
Tumor-specific genomic aberrations are routinely determined by high-throughput genomic measurements. It remains unclear how complex genome alterations affect molecular networks through changing protein levels and consequently biochemical states of tumor tissues.
RESULTS
Here, we investigate the propagation of genomic effects along the axis of gene expression during prostate cancer progression. We quantify genomic, transcriptomic, and proteomic alterations based on 105 prostate samples, consisting of benign prostatic hype
Additional indexing
Creators (Authors)
- Charmpi, Konstantina
- Guo, Tiannan
- Zhong, Qing
- Wagner, Ulrich
- Sun, Rui
- Toussaint, Nora C
- Fritz, Christine E
- Yuan, Chunhui
- Chen, Hao
- Rupp, Niels J
- Christiansen, Ailsa
- Rutishauser, Dorothea
- Rüschoff, Jan H
- Fankhauser, Christian
- Saba, Karim
- Poyet, Cedric
- Hermanns, Thomas
- Oehl, Kathrin
- Moore, Ariane L
- Beisel, Christian
- Calzone, Laurence
- Martignetti, Loredana
- Zhang, Qiushi
- Zhu, Yi
- Martínez, María Rodríguez
- Manica, Matteo
- Haffner, Michael C
- Aebersold, Ruedi
- Wild, Peter J
- Beyer, Andreas
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Citations
Charmpi, K., Guo, T., Zhong, Q., Wagner, U., Sun, R., Toussaint, N. C., Fritz, C. E., Yuan, C., Chen, H., Rupp, N. J., Christiansen, A., Rutishauser, D., Rüschoff, J. H., Fankhauser, C., Saba, K., Poyet, C., Hermanns, T., Oehl, K., Moore, A. L., … Beyer, A. (2020). Convergent network effects along the axis of gene expression during prostate cancer progression. Genome Biology, 21, 302. https://doi.org/10.1186/s13059-020-02188-9
