Publication: Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia
Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia
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Gialluisi, A., Andlauer, T. F. M., Mirza-Schreiber, N., Moll, K., Becker, J., Hoffmann, P., Ludwig, K. U., Czamara, D., Pourcain, B. S., Honbolygó, F., Tóth, D., Csépe, V., Huguet, G., Chaix, Y., Iannuzzi, S., Demonet, J.-F., Morris, A. P., Hulslander, J., Willcutt, E. G., … et al. (2021). Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia. Molecular Psychiatry, 26(7), 3004–3017. https://doi.org/10.1038/s41380-020-00898-x
Abstract
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Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40-60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried out a genome-wide association study (GWAS) on 2274 dyslexia cases and 6272 controls, testing associations at the single variant, gene, and pathway level, and estimating heritability using single-nucleotide polymorphism (SNP) data. We also
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- Gialluisi, Alessandro
- Andlauer, Till F M
- Mirza-Schreiber, Nazanin
- Moll, Kristina
- Becker, Jessica
- Hoffmann, Per
- Ludwig, Kerstin U
- Czamara, Darina
- Pourcain, Beate St
- Honbolygó, Ferenc
- Tóth, Dénes
- Csépe, Valéria
- Huguet, Guillaume
- Chaix, Yves
- Iannuzzi, Stephanie
- Demonet, Jean-Francois
- Morris, Andrew P
- Hulslander, Jacqueline
- Willcutt, Erik G
- DeFries, John C
- Olson, Richard K
- Smith, Shelley D
- Pennington, Bruce F
- Vaessen, Anniek
- Maurer, Urs
- Lyytinen, Heikki
- Peyrard-Janvid, Myriam
- Leppänen, Paavo H T
- Brandeis, Daniel
- Bonte, Milene
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Gialluisi, A., Andlauer, T. F. M., Mirza-Schreiber, N., Moll, K., Becker, J., Hoffmann, P., Ludwig, K. U., Czamara, D., Pourcain, B. S., Honbolygó, F., Tóth, D., Csépe, V., Huguet, G., Chaix, Y., Iannuzzi, S., Demonet, J.-F., Morris, A. P., Hulslander, J., Willcutt, E. G., … et al. (2021). Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia. Molecular Psychiatry, 26(7), 3004–3017. https://doi.org/10.1038/s41380-020-00898-x
