Publication: The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment
The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment
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de Vallière, C., Vidal, S., Clay, I., Jurisic, G., Tcymbarevich, I., Lang, S., Ludwig, M.-G., Okoniewski, M., Eloranta, J. J., Kullak-Ublick, G. A., Wagner, C. A., Rogler, G., & Seuwen, K. (2015). The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment. American Journal Of Physiology. Gastrointestinal And Liver Physiology, 309(6), 475–490. https://doi.org/10.1152/ajpgi.00408.2014
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The pH-sensing receptor ovarian cancer G protein-coupled receptor 1 (OGR1; GPR68) is expressed in the gut. Inflammatory bowel disease is typically associated with a decrease in local pH, which may lead to altered epithelial barrier function and subsequent gastrointestinal repair involving epithelial cell adhesion and migration. As the mechanisms underlying the response to pH changes are not well understood, we have investigated OGR1-mediated, pH-dependent signaling pathways in intestinal epithelial cells. Caco-2 cells stably overexpre
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- de Vallière, Cheryl
- Vidal, Solange
- Clay, Ieuan
- Jurisic, Giorgia
- Tcymbarevich, Irina
- Lang, Silvia
- Ludwig, Marie-Gabrielle
- Okoniewski, Michal
- Eloranta, Jyrki J
- Kullak-Ublick, Gerd A
- Wagner, Carsten A
- Rogler, Gerhard
- Seuwen, Klaus
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Publications of Clinic for Clinical Pharmacology and Toxicology
Publications of Clinic for Gastroenterology and Hepatology
Publications of Functional Genomics Center Zurich
Publications of Institute of Physiology
Publications of Zurich Center for Integrative Human Physiology (ZIHP)
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de Vallière, C., Vidal, S., Clay, I., Jurisic, G., Tcymbarevich, I., Lang, S., Ludwig, M.-G., Okoniewski, M., Eloranta, J. J., Kullak-Ublick, G. A., Wagner, C. A., Rogler, G., & Seuwen, K. (2015). The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment. American Journal Of Physiology. Gastrointestinal And Liver Physiology, 309(6), 475–490. https://doi.org/10.1152/ajpgi.00408.2014
