Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system

Petrinovic, M M; Duncan, C S; Bourikas, D; Weinman, O; Montani, L; Schroeter, A; Maerki, D; Sommer, L; Stoeckli, E T; Schwab, M E

doi:10.1242/dev.048371

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Petrinovic, M. M., Duncan, C. S., Bourikas, D., Weinman, O., Montani, L., Schroeter, A., Maerki, D., Sommer, L., Stoeckli, E. T., & Schwab, M. E. (2010). Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system. Development, 137(15), 2539–2550. https://doi.org/10.1242/dev.048371

Abstract

Wiring of the nervous system is a multi-step process involving complex interactions of the growing fibre with its tissue environment and with neighbouring fibres. Nogo-A is a membrane protein enriched in the adult central nervous system (CNS) myelin, where it restricts the capacity of axons to grow and regenerate after injury. During development, Nogo-A is also expressed by neurons but its function in this cell type is poorly known. Here, we show that neutralization of neuronal Nogo-A or Nogo-A gene ablation (KO) leads to longer neuri