Publication: A comparative study of g-quadruplex unfolding and DNA reeling activities of human RECQ5 helicase
A comparative study of g-quadruplex unfolding and DNA reeling activities of human RECQ5 helicase
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Budhathoki, J. B., Maleki, P., Roy, W. A., Janscak, P., Yodh, J. G., & Balci, H. (2016). A comparative study of g-quadruplex unfolding and DNA reeling activities of human RECQ5 helicase. Biophysical Journal, 110, 2585–2596. https://doi.org/10.1016/j.bpj.2016.05.016
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RECQ5 is one of five members of the RecQ family of helicases in humans, which include RECQ1, Bloom (BLM), Werner (WRN), RECQ4, and RECQ5. Both WRN and BLM have been shown to resolve G-quadruplex (GQ) structures. Deficiencies in unfolding GQ are known to result in DNA breaks and genomic instability, which are prominent in Werner and Bloom syndromes. RECQ5 is significant in suppressing sister chromatid exchanges during homologous recombination but its GQ unfolding activity are not known. We performed single-molecule studies under differ
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- Budhathoki, Jagat B
- Maleki, Parastoo
- Roy, William A
- Janscak, Pavel
- Yodh, Jaya G
- Balci, Hamza
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Budhathoki, J. B., Maleki, P., Roy, W. A., Janscak, P., Yodh, J. G., & Balci, H. (2016). A comparative study of g-quadruplex unfolding and DNA reeling activities of human RECQ5 helicase. Biophysical Journal, 110, 2585–2596. https://doi.org/10.1016/j.bpj.2016.05.016
