Clinical, serological and echocardiographic examination of healthy field dogs before and after vaccination with a commercial tetravalent leptospirosis vaccine

Spiri, Andrea Monika; Rodriguez-Campos, Sabrina; Matos, José M; Glaus, Toni M; Riond, Barbara; Reusch, Claudia E; Hofmann-Lehmann, Regina; Willi, Barbara

doi:10.1186/s12917-017-1056-x

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Spiri, A. M., Rodriguez-Campos, S., Matos, J. M., Glaus, T. M., Riond, B., Reusch, C. E., Hofmann-Lehmann, R., & Willi, B. (2017). Clinical, serological and echocardiographic examination of healthy field dogs before and after vaccination with a commercial tetravalent leptospirosis vaccine. BMC Veterinary Research, 13(1), 138. https://doi.org/10.1186/s12917-017-1056-x

Abstract

BACKGROUND: Leptospirosis is a re-emerging bacterial zoonosis caused by spirochetes of the genus Leptospira. Severe disease has been reported in dogs in Europe despite vaccination with bivalent Leptospira vaccines. Recently, a tetravalent canine Leptospira vaccine (Nobivac® L4) was licenced in Europe. The goal of this study was to investigate clinical signs, microscopic agglutination test (MAT) titres, haematology, blood biochemistry, cardiac (c) Troponin I levels and echocardiography before and after vaccination with this tetravalent