BRD9 is a druggable component of interferon-stimulated gene expression and antiviral activity

Börold, Jacob; Eletto, Davide; Busnadiego, Idoia; Mair, Nina K; Moritz, Eva; Schiefer, Samira; Schmidt, Nora; Petric, Philipp P; Wong, W Wei-Lynn; Schwemmle, Martin; Hale, Benjamin G

doi:10.15252/embr.202152823

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Börold, J., Eletto, D., Busnadiego, I., Mair, N. K., Moritz, E., Schiefer, S., Schmidt, N., Petric, P. P., Wong, W. W.-L., Schwemmle, M., & Hale, B. G. (2021). BRD9 is a druggable component of interferon-stimulated gene expression and antiviral activity. EMBO Reports, 22(10), e52823. https://doi.org/10.15252/embr.202152823

Abstract

Interferon (IFN) induction of IFN-stimulated genes (ISGs) creates a formidable protective antiviral state. However, loss of appropriate control mechanisms can result in constitutive pathogenic ISG upregulation. Here, we used genome-scale loss-of-function screening to establish genes critical for IFN-induced transcription, identifying all expected members of the JAK-STAT signaling pathway and a previously unappreciated epigenetic reader, bromodomain-containing protein 9 (BRD9), the defining subunit of non-canonical BAF (ncBAF) chromati