Bile acids in drug induced liver injury: Key players and surrogate markers

Schadt, Heiko S; Wolf, Armin; Pognan, Francois; Chibout, Salah-Dine; Merz, Michael; Kullak-Ublick, Gerd A

doi:10.1016/j.clinre.2015.12.017

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Schadt, H. S., Wolf, A., Pognan, F., Chibout, S.-D., Merz, M., & Kullak-Ublick, G. A. (2016). Bile acids in drug induced liver injury: Key players and surrogate markers. Clinics and Research in Hepatology and Gastroenterology, 40(3), 257–266. https://doi.org/10.1016/j.clinre.2015.12.017

Abstract

Bile acid research has gained great momentum since the role of bile acids as key signaling molecules in the enterohepatic circulation was discovered. Their physiological function in regulating their own homeostasis, as well as energy and lipid metabolism make them interesting targets for the pharmaceutical industry in the context of diseases such as bile acid induced diarrhea, bile acid induced cholestasis or nonalcoholic steatohepatitis. Changes in bile acid homeostasis are also linked to various types of drug-induced liver injury (D