Publication: Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
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Prota, A. E., Bargsten, K., Zurwerra, D., Field, J. J., Díaz, J. F., Altmann, K.-H., & Steinmetz, M. O. (2013). Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents. Science, 339(6119), 587–590. https://doi.org/10.1126/science.1230582
Abstract
Abstract
Abstract
Microtubule-stabilizing agents (MSAs) are efficacious chemotherapeutic drugs widely used for the treatment of cancer. Despite the importance of MSAs for medical applications and basic research, their molecular mechanisms of action on tubulin and microtubules remain elusive. Here we determined high-resolution crystal structures of aß-tubulin in complex with two unrelated MSAs, zampanolide and epothilone A. Both compounds were bound to the taxane-pocket of ß-tubulin and used their respective side chain to induce structuring of the M-loo
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- Prota, Andrea E
- Bargsten, Katja
- Zurwerra, Didier
- Field, Jessica J
- Díaz, José Fernando
- Altmann, Karl-Heinz
- Steinmetz, Michel O
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Prota, A. E., Bargsten, K., Zurwerra, D., Field, J. J., Díaz, J. F., Altmann, K.-H., & Steinmetz, M. O. (2013). Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents. Science, 339(6119), 587–590. https://doi.org/10.1126/science.1230582
