The making of the oral microbiome in Agta hunter–gatherers

Dobon, Begoña; Musciotto, Federico; Mira, Alex; Greenacre, Michael; Schlaepfer, Rodolph; Aguileta, Gabriela; Astete, Leonora H; Ngales, Marilyn; Latora, Vito; Battiston, Federico; Vinicius, Lucio; Migliano, Andrea B; Bertranpetit, Jaume

doi:10.1017/ehs.2023.9

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Dobon, B., Musciotto, F., Mira, A., Greenacre, M., Schlaepfer, R., Aguileta, G., Astete, L. H., Ngales, M., Latora, V., Battiston, F., Vinicius, L., Migliano, A. B., & Bertranpetit, J. (2023). The making of the oral microbiome in Agta hunter–gatherers. Evolutionary Human Sciences, 5, e13. https://doi.org/10.1017/ehs.2023.9

Abstract

Ecological and genetic factors have influenced the composition of the human microbiome during our evolutionary history. We analysed the oral microbiota of the Agta, a hunter–gatherer population where some members have adopted an agricultural diet. We show that age is the strongest factor modulating the microbiome, probably through immunosenescence since we identified an increase in the number of species classified as pathogens with age. We also characterised biological and cultural processes generating sexual dimorphism in the oral mi