Publication: Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling
Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling
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Lun, X.-K., Szklarczyk, D., Gábor, A., Dobberstein, N., Zanotelli, V. R. T., Saez-Rodriguez, J., von Mering, C., & Bodenmiller, B. (2019). Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling. Molecular Cell, 74(5), 1086-1102.e5. https://doi.org/10.1016/j.molcel.2019.04.021
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Kinase and phosphatase overexpression drives tumorigenesis and drug resistance. We previously developed a mass-cytometry-based single-cell proteomics approach that enables quantitative assessment of overexpression effects on cell signaling. Here, we applied this approach in a human kinome- and phosphatome-wide study to assess how 649 individually overexpressed proteins modulated cancer-related signaling in HEK293T cells in an abundance-dependent manner. Based on these data, we expanded the functional classification of human kinases an
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- Szklarczyk, Damian
- Gábor, Attila
- Dobberstein, Nadine
- Zanotelli, Vito R T
- Saez-Rodriguez, Julio
- Bodenmiller, Bernd
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Lun, X.-K., Szklarczyk, D., Gábor, A., Dobberstein, N., Zanotelli, V. R. T., Saez-Rodriguez, J., von Mering, C., & Bodenmiller, B. (2019). Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling. Molecular Cell, 74(5), 1086-1102.e5. https://doi.org/10.1016/j.molcel.2019.04.021
